Distribution of olfactory receptor genes in the human genome
- 1 March 1998
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 18 (3), 243-250
- https://doi.org/10.1038/ng0398-243
Abstract
We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.This publication has 35 references indexed in Scilit:
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