Use of microfibrillar collagen as a topical hemostatic agent in brain tissue

Abstract

Microfibrillar collagen, a recently introduced topical hemostatic agent, was used to obtain hemostasis in suction-evacuation lesions of canine cortex. Gelatin foam was used as a control in identical lesions on the opposite side. Microfibrillar collagen was faster acting and more effective than gelatin foam. Histological evaluation of the lesions at 2, 4 and 6 mo. postoperatively showed no significant difference in the amount or type of tissue reaction to the 2 agents.