Sarcoidosis

Abstract

Anatomic arguments. The histologic resemblance of the sarcoid lesion to the "hard" tubercle produced by the tubercle bacillus under certain conditions cannot be denied. Certain animals, such as the rat, also react rather characteristically to this organism with productive noncaseating tubercles.^{4, 228} However, identical histologic lesions can be produced in man by such varied agents as those of leprosy and syphilis, and even by beryllium compounds, and the various lesions of tuberculosis itself can be mimicked in every detail by other agents, such as silica.²²⁹ Although tubercles may apparently persist in recognizable form after the organisms that produced them have . . .