The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse
- 1 August 1995
- journal article
- Published by Springer Nature in Mammalian Genome
- Vol. 6 (8), 491-492
- https://doi.org/10.1007/bf00356163
Abstract
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.Keywords
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