Sensitivity of Mice to Endotoxin after Vaccination with BCG (Bacillus Calmette-Guerin)
- 1 October 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 99 (1), 167-169
- https://doi.org/10.3181/00379727-99-24282
Abstract
Mice given a single intravenous injection of a culture of BCG(attenuated tubercle bacilli) develop a state of hyperreactivity to bacterial endotoxin (lipopolysaccharide). The LD50 for Escherichia coli lipopolysaccharide decreases from 357 [mu]g in controls to 6 or 7 [mu]g 7 days after vaccination. This hyperreactivity persists for several months. Cord factor derived from virulent tubercle bacilli induces a similar state of hyperreactivity.Keywords
This publication has 3 references indexed in Scilit:
- Hyperreactivity of Coxiella burnetii Infected Guinea Pigs to Subsequent Injections of Bacterial EndotoxinsExperimental Biology and Medicine, 1957
- Homologous and Heterologous Resistance in Mice Given Bacterial EndotoxinsThe Journal of Immunology, 1957
- REVERSIBLE CHANGES IN THE SUSCEPTIBILITY OF MICE TO BACTERIAL INFECTIONSThe Journal of Experimental Medicine, 1956