Prevalence of neuroendocrine granules in small cell lung carcinoma. Usefulness of electron microscopy in lung cancer classification
- 1 May 1986
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 149 (1), 41-47
- https://doi.org/10.1002/path.1711490109
Abstract
Fifty-four lung carcinomas submitted for routine electron microscopy under the light microscopical diagnosis of small cell carcinoma were investigated. In 42 or of 45 evaluable cases, neuroendocrine granules were considered definitely or probably present, the modification ‘probably’ being necessary in suboptimal material. In three cases, squamous cell differentiation was seen, but no neuroendocrine granules were found. On revision of these three cases, the light microscopical diagnosis was changed to squamous cell carcinoma in one instance, and neither of the other two cases was considered classical for small cell carcinoma. Patient follow-up of these three cases showed tumour behaviour indicative of non-small cell carcinoma in two evaluable cases, the third case yielding no significant data. These results indicate that neuroendocrine granules can generally be found in small cell lung carcinomas, provided the material is sufficient for evaluation. When these granules are absent, and other differentiation is found on electron microscopy, the final classification of the tumour should incorporate this finding, to warn the clinician that the tumour will not necessarily behave as a small cell carcinoma.Keywords
This publication has 24 references indexed in Scilit:
- Current status of therapy for small cell carcinoma of the lungCancer, 1984
- The prognostic significance of histologic subtyping in small cell carcinoma of the lungAmerican Journal of Clinical Oncology, 1984
- Electron microscopy in small cell lung carcinomas: clinical correlation.Journal of Clinical Oncology, 1984
- New Techniques Rapid Deparaffinization for Electron MicroscopyUltrastructural Pathology, 1984
- Pulmonary small cell carcinoma showing tripartite differentiation in individual cellsHuman Pathology, 1981
- Small cell squamous and mixed small cell squamous—small cell anaplastic carcinomas of the lungThe American Journal of Surgical Pathology, 1980
- Comparative Histopathologic, Histochemical, Electron Microscopic and Tissue Culture Studies of Bronchial Carcinoids and Oat Cell Carcinomas of LungAmerican Journal of Clinical Pathology, 1978
- Rapid chemical dehydration of samples for electron microscopic examinations.Journal of Histochemistry & Cytochemistry, 1975
- Oat-cell carcinoma of the lung. Clinical and morphological studies in relation to its histogenesisCancer, 1972
- Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoidCancer, 1968