Effect of Intravenously Administered Iodipamide Ethyl Ester Particles on Rat Liver Morphology

Abstract

The effect of i.v. injected iodipamide ethyl ester (IDE) particles (150 mgI/kg) on the rat liver was studied by light microscopy and EM. IDE particles were phagocytized by Kupffer cells within a few minutes postinjection. After 4 h particles began to dissolve in the Kupffer cells causing transient morphologic alterations resembling hydropic degeneration. The number of Kupffer cells seemed, however, to be unchanged and were ultrastucturally normal by 17 days postinjection. Hepatocytes contained large lipid droplets from 1 to 4 days after IDE injection. No changes were found in the hepatocytes from 1 wk to 1 yr after IDE injection. The fat-storing cells and endothelial cells remained ultrastructurally normal throughout the study.