ABSENCE OF EFFECT OF BOVINE GROWTH HORMONE ON BLOOD SUGAR OF HOUSSAY DOGS

Abstract

A highly purified growth hormone preparation (Wilhelmi) was tested for its hypoglycemic activity in four fasting, hypophysectomized–depancreatized dogs (Houssay dogs) maintained without exogenous insulin for 2–4 weeks. A single intravenous injection of growth hormone, 5 mg per kg body weight, had no effect on blood sugar over a period of 6 hours. It was concluded that highly purified growth hormone has no hypoglycemic effect in the absence of biologically active insulin.