Increased Radiosensitivity of Skin Fibroblasts in Friedreich’s Ataxia
- 1 January 1981
- book chapter
- Published by Springer Nature
- Vol. 7, 230-232
- https://doi.org/10.1007/978-3-642-81553-9_68
Abstract
Fibroblasts from forearm skin biopsy specimens from 3 patients with Friedreich’s ataxia and controls without evidence of hypersensitivity to ionising radiation were exposed to a range of doses of gamma or x-rays up to 550 rad, and cell survival was measured by counting clones derived from single fibroblasts. Cells from two of the three Friedreich cases were found to have an abnormally low survival at the dose levels used, the difference from controls run in parallel being significant. These findings suggest the possibility of defective DNA repair processes in at least some patients with Friedreich’s ataxia.Keywords
This publication has 8 references indexed in Scilit:
- INCREASED SENSITIVITY TO GAMMA IRRADIATION OF SKIN FIBROBLASTS IN FRIEDREICH'S ATAXIAThe Lancet, 1979
- Ataxia telangiectasia. Evaluation of radiosensitivity in cultured skin fibroblasts as a diagnostic test.Archives of Disease in Childhood, 1978
- Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation.Proceedings of the National Academy of Sciences, 1978
- Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitiveNature, 1977
- Ataxia telangiectasia: a human mutation with abnormal radiation sensitivityNature, 1975
- Changes in Radiosensitivity during thein VitroGrowth of Diploid Human FibroblastsInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1974
- Xeroderma PigmentosumPublished by American Medical Association (AMA) ,1969
- Pathological findings in three cases of ataxia-telangiectasiaJournal of Neurology, Neurosurgery & Psychiatry, 1966