The glycolytic enzymes of guinea-pig lung in experimental bagassosis

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Abstract
The activity of certain glycolytic enzymes, namely phosphorylase, hexokinase, phosphoglucoisomerase and aldolase, was estimated in lungs of guinea pigs which have been exposed to bagasse dust and was compared with that of normal guinea-pig lungs. Phosphorylase activity was unaltered, whereas the activities of the other 3 enzymes were significantly increased in experimental bagassosis. The lactic acid content was increased in the lungs of guinea pigs exposed to bagasse dust as compared with those of normal ones. The significance of the results in explaining the increased glycogen content of guinea-pig lung in experimental bagassosis is discussed.