A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart.
- 1 January 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (1), 101-105
- https://doi.org/10.1073/pnas.74.1.101
Abstract
The prostaglandins (PGs) released from the heart have generally been characterized as resembling PGE by bioassay techniques. The major PG formed from [14C]arachidonate (C20:4) by the isolated perfused rabbit heart has chromatographic mobility similar to that of PGE2 in most solvent systems. However, additional analysis of this radioactive "PGE" peak suggests that two substances are formed by the heart and migrate like PGE2: one has chemical properties similar to those of authentic PGE2 and the other is a novel PG. The unknown compound is the major PG formed by the heart from either exogenous arachidonate or hormonal stimulation of PG biosynthesis. The novel PG produced by the heart may be identical with either 6(9)-oxy-PGF or 6-keto-PGF1 alpha.This publication has 17 references indexed in Scilit:
- Selective incorporation of 14C-arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to 14C-prostaglandinsProstaglandins, 1976
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomachJournal of the American Chemical Society, 1976
- The importance of phospholipase-A2 in prostaglandin biosynthesisBiochemical Pharmacology, 1976
- Hormone interactions in the isolated rabbit heart. Synthesis and coronary vasomotor effects of prostaglandins, angiotensin, and bradykinin.Circulation Research, 1975
- Prostaglandins and the regulation of uterine blood flow in pregnancyNature, 1974
- Hypoxia Causes Prostaglandin Release from Perfused Rabbit HeartsActa Physiologica Scandinavica, 1974
- Isolation and properties of intermediates in prostaglandin biosynthesisBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenatesBiochemistry, 1971
- Phospholipid precursors of prostaglandinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968