The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat
- 1 November 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (11), 850-852
- https://doi.org/10.1111/j.2042-7158.1986.tb04510.x
Abstract
The diuretic and adenosine antagonist actions of two alkylxanthines have been compared in the conscious rat. 8-Phenyltheophylline (10 mg kg−1) antagonized adenosine-induced bradycardia in the rat for at least 3 h whereas enprofylline (10 mg kg−1) had no effect on this response. 8-Phenyltheophylline (10 mg kg−1) evoked diuresis and saliuresis in the rat whereas enprofylline (10 mg kg−1) had no effect on excretory parameters. These results indicate that the diuretic action of some alkylxanthines may be related to adenosine antagonism.This publication has 8 references indexed in Scilit:
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