Nonsyphilitic Interstitial Keratitis and Bilateral Deafness (Cogan's Syndrome) Associated with Cardiovascular Disease

Abstract

NONSYPHILITIC interstitial keratitis with vestibuloauditory symptoms was first recognized as a clinical entity by Cogan^{1 , 2} in 1945. This syndrome usually occurs in young adults and is of sudden onset, initiating with either the ocular or the aural manifestations. The symptoms of both systems may occur almost simultaneously or may be delayed for several months, but usually appear within a few weeks of each other. The vestibuloauditory symptoms are similar to those seen in Ménière's syndrome and consist of sudden onset of vertigo, tinnitus, nausea, vomiting and rapid development of deafness. With the appearance of deafness, which is often complete, the . . .