Synthesis and structure determination of FR109615, a new antifungal antibiotic.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (5), 513-518
- https://doi.org/10.7164/antibiotics.43.513
Abstract
The structure of FR109615, a new antifungal antibiotic, was determined to be (1R, 2S)-2-aminocyclopentane-l-carboxylic acid ((-)-cis-2-ACPC: 8a) by X-ray analysis. (-)-cis-2-ACPC (8a) was also synthesized via optical resolution of 3a and 3b derived from (±)-cis-2-ACPC hydrochloride (1). 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity.This publication has 2 references indexed in Scilit:
- FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.The Journal of Antibiotics, 1990
- Method for Determination of the Amino Acid Sequence in Peptides.Acta Chemica Scandinavica, 1950