Trimethoprim-Sulfamethoxazole: Absorption, Excretion, and Toxicity in Six Children

Abstract

Five infants, seven to 17 months old, and an 11-year-old child were treated with 185 mg of trimethoprim (TMP) plus 925 mg of sulfamethoxazole (SMZ) per m² daily in two equal doses. Peak levels were observed in the blood between 1 and 4 hr, and high levels of activity were sustained for 12 hr after the first and subsequent doses. There was no significant accumulation of TMP and SMZ. A beneficial therapeutic effect was achieved in all six patients. Granulocytopenia was observed in one child, the recipient of a renal transplant who was receiving immunosuppressive drugs concurrently.