Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion
- 19 August 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 188 (1), 81-84
- https://doi.org/10.1016/0014-5793(85)80879-6
Abstract
Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA8) at its C-terminal end. In this study, the effect of OXM and KA8 on pentagastrin-stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25–450 pmol·kg−1) as well as KA8 (7.5–60 nmol·kg−1) inhibited pentagastrin-stimulated gastric acid output in a dose-dependent manner; KA8 was about 100-times less potent than OXM. In cats, KA8 (90 nmol·kg−1) was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C-terminal octapeptide of OXM is implicated in this effectKeywords
This publication has 5 references indexed in Scilit:
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