PENETRATION OF PENICILLIN IN RABBIT EYES WITH NORMAL, INFLAMED AND ABRADED CORNEAS

Abstract

PENETRABILITY OF PENICILLIN Struble and Bellows¹ pointed out that in the evaluation of any chemotherapeutic agent the efficiency of the agent depends not only on its antibacterial potency but on its diffusibility and its concentration in the infected part. Von Sallmann and Meyer² and Struble and Bellows¹ studied the penetration of penicillin in the normal eyes of rabbits and dogs. Von Sallmann and Meyer² were unable to demonstrate any antibacterial activity of penicillin in the aqueous humor after repeated applications of solutions and ointments containing penicillin to the normal rabbit eye, but obtained high levels of penicillin in the aqueous with the corneal bath and iontophoretic technics. Struble and Bellows¹ also demonstrated high concentrations of penicillin in the aqueous humor after corneal baths of penicillin and showed that the level in the cornea exceeded the level in the aqueous when the corneal bath technic was