A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.

Abstract

A new mast cell degranulating peptide was isolated from the frog skin. The peptide possesses a notable sequence, in which hydrophobic amino aicd residues are in the N-terminal, and hydrophilic and basic amino acid residues in the C-terminal region. Granuliberin-R belongs to a new family of the active peptides in the amphibian skin.