Association of D/D translocations with fetal wastage and aneuploidy. A report of four families.
- 1 October 1976
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 13 (5), 389-393
- https://doi.org/10.1136/jmg.13.5.389
Abstract
Four familes are described with a t(13q14q) segregating. Two of them were identified through index cases with Down''s syndrome; their karyotypes revealed the unusual 46, XY,-13,-14,+t(13q14q),+21. The other 2 families were identified through a chromosomal study of parents with repeated spontaneous abortions. Analysis of data on 3 of these 4 families and on 7 others from the published reports showed no evidence of increased fetal wastage among 13/14 carriers. The risk of producing offspring with various types of aneuploidy may be greater among carriers than among persons with a normal chromosome pattern. Qualitative and quantitative differences in D/D translocations may account for the observed variation in clinical findings. These differences add to the problem of determining genetic risks from an analysis of grouped data.This publication has 20 references indexed in Scilit:
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