Blood flow changes in transplanted mouse tumours and skin after mild hyperthermia

Abstract

The influence of moderate hyperthermia on the vascular perfusion of 4 tumor types and of normal mouse skin was investigated. The 86Rb extraction technique was used to measure changes in perfusion relative to total cardiac output, both during and after a 1 h heat treatment at 42.5.degree. C. Perfusion of the SA FA tumor increased slightly during the first 30 min of heating but had returned to control values by the end of a 1 h heating period. After heating, the relative perfusion of all 4 tumor types fell significantly below control values by 24 h and remained low for 1-2 days (SA FA tumor) before returning to control values. Relative perfusion of normal skin was progressively increased during heating and remained elevated for 24 h after the end of treatment before returning to control levels. [There is substantial experimental and clinical interest in the use of hyperthermia for the treatment of cancer.].