The NF1 Gene in Myelopoiesis and Childhood Myelodysplastic Syndromes
- 3 March 1994
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 330 (9), 637-639
- https://doi.org/10.1056/nejm199403033300912
Abstract
Molecular investigations of cancer cells have identified genes, proteins, and biochemical pathways that may be useful for diagnosing and classifying cancer, formulating a prognosis, or identifying people who are predisposed to cancer. These studies have revealed two classes of genes related to cancer: proto-oncogenes and tumor-suppressor genes. The latter are now under intense scrutiny; nine tumor-suppressor genes have been identified by molecular cloning techniques (three in the past year1), and investigations of a variety of cancers suggest the existence of at least two dozen others.Evidence implicating suppressor genes in the cause of cancer comes mainly from studies of . . .Keywords
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