Requirement for DCP-1 Caspase During Drosophila Oogenesis
- 9 January 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 279 (5348), 230-234
- https://doi.org/10.1126/science.279.5348.230
Abstract
Caspases, a class of cysteine proteases, are an essential component of the apoptotic cell death program. DuringDrosophila oogenesis, nurse cells transfer their cytoplasmic contents to developing oocytes and then die. Loss of function for thedcp-1 gene, which encodes a caspase, caused female sterility by inhibiting this transfer. dcp-1 − nurse cells were defective in the cytoskeletal reorganization and nuclear breakdown that normally accompany this process. Thedcp-1 − phenotype suggests that the cytoskeletal and nuclear events in the nurse cells make use of the machinery normally associated with apoptosis and that apoptosis of the nurse cells is a necessary event for oocyte development.Keywords
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