Comparison of Outward and Inward Na+/k+Cotransport-Mediated Fluxes in Erythrocytes of Essential Hypertensive Patients. Preliminary Results
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension
- Vol. 3 (4), 809-814
- https://doi.org/10.3109/10641968109033704
Abstract
A hereditary defect in the outward ouabain-resistant, furosemide-sensitive (ORFS) Na+/K+ cotransport has recently been reported by Garay and Meyer in erythrocytes of essential hypertensive patients and some of their normotensive offsprings. Since Na+/K+ cotransport in erythrocytes operates bidirectionally, the same defect might be detectable in the ORFS component of K+ influx rate. To test this hypothesis outward and inward Na+/K+ cotransport measurements were performed in erythrocytes of hypertensives and normotensive controls. Our preliminary results confirm the observation of a reduced outward cotransport in essential hypertension and also suggest that inward cotransport may be reduced in essential hypertension.Keywords
This publication has 4 references indexed in Scilit:
- A Na+,K+ co-transport assay for essential hypertensionCanadian Journal of Biochemistry, 1980
- Inherited defect in a Na+, K+ -co-transport system in erythrocytes from essential hypertensive patientsNature, 1980
- cAMP-stimulated cation cotransport in avian erythrocytes: inhibition by "loop" diureticsAmerican Journal of Physiology-Cell Physiology, 1980
- A Furosemide-Sensitive Cotransport of Sodium plus Potassium in the Human Red CellJCI Insight, 1974