Jaundice Associated with Isocarboxazid Therapy

Abstract

THE introduction of iproniazid phosphate§ therapy for the treatment of tuberculosis also revealed its effectiveness in mental disorders, particularly depressions. After the use of iproniazid became more widespread, reports of cases of associated jaundice began to appear.^{1 2 3} The effectiveness of iproniazid, an amine oxidase inhibitor, in the therapy of mental depressions caused further investigation for a less toxic analogue. The results of these investigations produced isocarboxazid (1-benzyl-2, 5-methyl-3-isoxazolylcarbonyl hydrazine).¶ This drug is related in its mode of action to iproniazid, with which it compares favorably in its effectiveness both in angina pectoris and in depressions, but it has substantially fewer . . .