Timed-Disintegration Capsules

Abstract

THE purpose of timed-disintegration capsules is to provide sustained therapeutic effect throughout the daytime period by administration of a single capsule in the morning. In this way the inconvenience and uncertainty attending administration of the drug three times daily are eliminated.Timed disintegration may be accomplished by incorporation inside the capsule of a number of tiny pellets variously coated for different disintegration intervals to cover the desired span of action.LiteratureVery little has been published on the subject of timed-disintegration capsules. In describing the dosage of dextroamphetamine sulfate, New and Nonofficial Remedies ¹ 1955 states: "A capsule containing 10 or . . .