Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline.
Open Access
- 1 June 1975
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 2 (3), 227-232
- https://doi.org/10.1111/j.1365-2125.1975.tb01580.x
Abstract
1 Hospitalized patients suffering from insomnia were treated with N-demethyldiazepam (30 mg p.o.) for 10 days, while continuing treatment with nortriptyline (75 or 100 mg daily). 2 Clinical evaluation performed by objective rating scales showed a positive therapeutic effect. No correlation was found however between drug plasma levels and clinical efficacy. A high inter-individual variability was observed. 3 In three cases the N-demethyldiazepam disappearance curve showed a biexponential decay, with a slow first component followed by a faster one. 4 Compared with diazepam the tested drug has a longer plasma apparent half-life and a lower relative clearance.Keywords
This publication has 15 references indexed in Scilit:
- Plasma concentrations of diazepam and of its metabolite N‐desmethyldiazepam in relation to anxiolytic effectClinical Pharmacology & Therapeutics, 1974
- The residual effects of N-desmethyldiazepam in patientsPsychopharmacology, 1974
- Pharmacokinetic Profile of Diazepam in Man following Single Intravenous and Oral and Chronic Oral AdministrationsJournal of Pharmaceutical Sciences, 1973
- Diazepam metabolism during chronic medication : Unbound fraction in plasma, erythrocytes and urineJournal of Chromatography A, 1973
- Diazepam elimination in premature and full term infants, and childrenjpme, 1973
- Determination of bioavailability of diazepam in various formulations from steady state plasma concentration dataClinical Pharmacology & Therapeutics, 1972
- Residual effects of hypnoticsPsychopharmacology, 1972
- Pharmacokinetics of Diazepam in Dogs, Mice and HumansActa Pharmacologica et Toxicologica, 1971
- Rate of accumulation and plateau plasma concentration of drugs after chronic medicationJournal of Pharmacy and Pharmacology, 1968
- Blood Levels of Drug at the Equilibrium State after Multiple DosingNature, 1965