The Distribution of Selenium in Plasma and Liver Proteins and Its Fractionation in Tryptic Liver Digests

Abstract

The quantitative distr. of Se in the various plasma and liver proteins in chronically poisoned rabbits and rats was reported. Se was found in all the proteins examined, though predominantly in the globulins. Tryptic digestion of selenized livers released about 80% of the Se from its protein combination. Fractionation of the protein-free filtrates of the liver digests showed that the Se compound or compounds was not removed by procedures commonly employed for the removal of histone bases from protein hydrolysates, and that it did not parallel the separation of cystine.