Transport and Metabolism of the Tea Flavonoid (–)-Epicatechin by the Human Intestinal Cell Line Caco-2
- 1 January 2001
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 18 (10), 1420-1425
- https://doi.org/10.1023/a:1012200805593
Abstract
Purpose:Tea flavonoids, including (–)-epicatechin (EC), have been suggested to have chemopreventive properties in cancer. However, there is limited knowledge of the oral bioavailability of these...Keywords
This publication has 26 references indexed in Scilit:
- Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.2001
- Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteersFree Radical Research, 2000
- Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistanceBiochimica et Biophysica Acta (BBA) - Biomembranes, 1999
- Transport of Quercetin and Its Glucosides across Human Intestinal Epithelial Caco-2 CellsBiochemical Pharmacology, 1998
- Taxol transport by human intestinal epithelial Caco-2 cells.1998
- (−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κBMolecular Pharmacology, 1997
- In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or MythPharmaceutical Research, 1997
- Tea and CancerJNCI Journal of the National Cancer Institute, 1993
- Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cellsBiochemical and Biophysical Research Communications, 1991
- Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) CellsJournal of Pharmaceutical Sciences, 1990