Evidence for thiophene-s-oxide as a primary reactive metabolite of thiophene in vivo: Formation of a dihydrothiophene sulfoxide mercapturic acid
- 14 August 1992
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 186 (3), 1624-1630
- https://doi.org/10.1016/s0006-291x(05)81594-3
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophilesJournal of the American Chemical Society, 1991
- Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes: Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylationBiochemical Pharmacology, 1991
- Oxidative activation of the thiophene ring by hepatic enzymesBiochemical Pharmacology, 1990
- Enzymatic activation of chemicals to toxic metabolitesCRC Critical Reviews in Toxicology, 1985
- Synthesis of Aromatic S-Sustituted Derivatives of N-Acetyl-L-cysteineAustralian Journal of Chemistry, 1985
- Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridineToxicology and Applied Pharmacology, 1977
- Arene Oxides: A New Aspect of Drug MetabolismScience, 1974
- The Metabolism of Thiophen in the Rabbit and the RatXenobiotica, 1971
- A Novel Synthesis of IsothianaphthenesJournal of the American Chemical Society, 1966