Genetic Variation in Coumarin Hydroxylase Activity in the Mouse ( Mus musculus )
- 16 August 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4151), 612-614
- https://doi.org/10.1126/science.185.4151.612
Abstract
Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F1 hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.Keywords
This publication has 15 references indexed in Scilit:
- Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic CarcinomaNew England Journal of Medicine, 1973
- Aryl Hydrocarbon Hydroxylase Induction in Human LeukocytesScience, 1972
- Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[ a ]anthraceneScience, 1972
- The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL/6J and DBA/2JBiochemical Genetics, 1972
- Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the MouseNature New Biology, 1972
- Warfarin metabolism in man: identification of metabolites in urineJCI Insight, 1970
- Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in manJCI Insight, 1969
- The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal statesArchives of Biochemistry and Biophysics, 1969
- Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic ReticulumPublished by Elsevier ,1966
- Insufficient parahydroxylation as a cause of diphenylhydantoin toxicityNeurology, 1964