Mutant Frequency of Radiotherapy Technicians Appears to Be Associated With Recent Dose of Ionizing Radiation
- 1 October 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Health Physics
- Vol. 57 (4), 537-544
- https://doi.org/10.1097/00004032-198910000-00003
Abstract
The frequency of hypoxanthine phosphoribosyl transferase (HPRT) mutants among peripheral T-lymphocytes of radiotherapy technicians primarily exposed to 60Co was measured by the T-cell cloning method. Mutant frequencies of these technicians in 1984 and 1986 were significantly higher than those of physiotherapy technicians who worked in a neighboring service, and correlated significantly with thermoluminescence dosimeter readings recorded during the 6 mo preceding mutant frequency determination. Correlations decreased when related to dose recorded over longer time intervals. HPRT mutant frequency determination in peripheral lymphocytes is a good measure of recently received biologically effective radiation dose in an occupationally exposed population.This publication has 11 references indexed in Scilit:
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