1:1:1-Trichloro-2:2-di-(p-chlorophenyl)ethane (DDT) and rat adipose tissue

Abstract

The deposition of glycogen in rat adipose tissue, which occurs after refeeding partially starved rats, was not affected by previously feeding the rats on l,l,l-trichloro-2,2-di(p-chlorophenyl)-ethane (DDT) at 200 ppm. Previous feeding of DDT did not affect the respiration in vitro of groin fat slices or the glucose uptake and unesterified fatty acid release by epididymal fat. The glucose uptake of epididymal fat was unaffected by the presence of 1,2,3,4,10,10-hexachloro-6,7-epoxy-l,4,4, a,5,6,7,8,8 [alpha]-octahydro-1,4,5,8-dimethanonaphthalene (Dieldrin) in the diet. Oxidation of glucose by brain slices occurred at normal rates in the presence of DDT, Dieldrin or 1,2,3,4,5,6-hexachlorocyclohexane. In contrast, en-zymic activities of rat-liver mitochondria were modified by the addition in vitro of DDT, Dieldrin, hexachlorocyclohexane or 2 metabolites of DDT.