DEVELOPMENTAL CHANGES IN THE EXPRESSION AND DISTRIBUTION OF CELLULAR RETINOIC ACID BINDING PROTEIN (CRABP) IN THE CENTRAL NERVOUS SYSTEM OF THE CHICK EMBRYO
- 1 January 1989
- journal article
- research article
- Published by Biomedical Research Press in Biomedical Research
- Vol. 10 (1), 43-48
- https://doi.org/10.2220/biomedres.10.43
Abstract
A large amount of cellular retinoic acid binding protein (CRABP), by which the action of retinoic acid is mediated, was present in the central nervous system as well as limb buds in the early developmental stages of chick embryo. The expression of CRABP in the brain was developmentally changed. The highest level of CRABP expression occurred during stages 22-28 and it gradually dispappeared thereafter. By stages 38-43, CRABP was not detected in the brain. At stage 25, CRABP was intensely expressed on both sides on the neural tubes where neuroblast cells proliferate and differentiate. The localization and the expression of CRABP in the central nervous system in the early developmental stages of chick embryo suggest the possibility that retinoic acid is involved in the differentiation and growth of neuronal cells during the development.This publication has 20 references indexed in Scilit:
- Lipid binding activities of the P2 protein in peripheral nerve myelinNeurochemical Research, 1984
- Selection and characterization of F9 teratocarcinoma stem cell mutants with altered responses to retinoic acid.Journal of Biological Chemistry, 1984
- The effect of local application of retinoic acid to the anterior margin of the developing chick limbDevelopment, 1983
- Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines.Proceedings of the National Academy of Sciences, 1983
- Radioimmunochemical determination of cellular retinol- and cellular retinoic acid-binding proteins in cytosols of rat tissues.Journal of Biological Chemistry, 1982
- Isolation and characterization of mouse mutant embryonal carcinoma cells which fail to differentiate in response to retinoic acid.Proceedings of the National Academy of Sciences, 1981
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- The induction of differentiation in teratocarcinoma stem cells by retinoic acidCell, 1978
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- A series of normal stages in the development of the chick embryoJournal of Morphology, 1951