URINE FORMATION UNDER ANOXIA IN DOGS

Abstract

Anoxia resulting from breathing gas mixtures of low 02, below 10%, in anesthetized dogs (Dial by stomach) with trachea, carotid artery, and ureters cannulated, generally resulted in oliguria, but occasionally in polyuria. In dogs with urinary bladder fistulas, the anoxia resulted in polyuria, whether the animals were anesthetized or not. The presence of CO2 in the inspired air did not alter significantly the renal responses to anoxia. There was no constant relationship between the urinary rate and the carotid blood pressure. The urinary urea and chloride concns. did not approach those of the plasma in either the sacrifice or the bladder-fistula dogs. The rates of urea and chloride excretion in both the sacrifice and fistula animals varied directly as the water excretion. The anoxia induced a condition of temporary glycosuria in the sacrifice dogs, and proteinuria in those sacrifice animals which responded with an oliguria. Anoxia in the fistula animals appeared to be without any effect on the urinary protein and sugar. Probably the increased secretion of epinephrine resulting from the anoxia was an important factor producing the above results.