Abstract
Summary Hemagglutination - inhibition (HI) antibodies appeared in the serum of mice 3 days after injection of influenza virus vaccine. The initial antibody was sensitive to 2-mercaptoethanol, sedimented as an 18s mac-roglobulin, and had a biologic half-life of 0.5 days. Antisera obtained approximately 2 weeks after vaccination contained antibody that resisted treatment with mercaptoethanol, sedimented as 7s γ-globulin, and had a half-life of 2 days.