Function of Myocardial Mitochondria in the Adriamycin-Induced Cardiomyopathy of Rabbits2
- 1 November 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 57 (5), 1091-1094
- https://doi.org/10.1093/jnci/57.5.1091
Abstract
Ultrastructural examination of the myocardia of New Zealand White rabbits showed a progressive cardiomyopathy with prominent mitochondrial lesions after 56 days of increased doses of adriamycin. During all phases of study, similar respiratory control rates and ADP:O ratios were found in myocardial mitochondria isolated from adriamycin-treated and control rabbits.Keywords
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