Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.
- 1 April 1982
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 13 (4), 547-552
- https://doi.org/10.1111/j.1365-2125.1982.tb01420.x
Abstract
1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy.Keywords
This publication has 18 references indexed in Scilit:
- PHENYTOIN BINDING IN PREGNANCYThe Lancet, 1980
- DECREASED SERUM PROTEIN BINDING OF PHENYTOIN IN LATE PREGNANCYThe Lancet, 1980
- METABOLISM OF DIPHENYLHYDANTOIN (PHENYTOIN) DURING PREGNANCYBJOG: An International Journal of Obstetrics and Gynaecology, 1979
- Antiepileptic DrugsClinical Pharmacokinetics, 1979
- Plasma anticonvulsant concentrations during pregnancyNeurology, 1977
- Plasma Drug Level Monitoring in PregnancyClinical Pharmacokinetics, 1977
- PHENYTOIN and PHENOBARBITONE PLASMA CLEARANCE DURING PREGNANCYActa Neurologica Scandinavica, 1976
- Epilepsy and Pregnancy: A Study of 153 Pregnancies in 59 PatientsEpilepsia, 1975
- Albumin standards and the measurement of serum albumin with bromcresol greenClinica Chimica Acta; International Journal of Clinical Chemistry, 1971
- Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatographyAnalytical Chemistry, 1970