Thyroxine-Binding Globulin: Specificity for the Hormonally Active Conformation of Triiodothyronine
- 13 October 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4057), 172-174
- https://doi.org/10.1126/science.178.4057.172
Abstract
The conformational requirements for binding of triiodothyronine to thyroxine-binding globulin were investigated with triiodothyronine analogs having restricted rotation at the ether bond. Although it has been reported that the predominant conformation of triiodothyronine carries the 3' iodine in a position proximal to the phenylalanine ring, the analog for the distal, hormonally active orientation of the 3' iodine is more effective in displacing triiodothyronine and thyroxine from thyroxine-binding globulin. The lower binding affinity of thyroxine-binding globulin for triiodothyronine as compared to thyroxine may be explained by specificity of the binding site for the less abundant conformation of triiodothyronine.Keywords
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