Sickling of Erythrocytes in a Patient with Thalassemia-Hemoglobin-I Disease
- 15 December 1960
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 263 (24), 1215-1223
- https://doi.org/10.1056/nejm196012152632402
Abstract
IN 1955 Rucknagel et al.1 described a new abnormal hemoglobin in a Negro family in North Carolina. This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper electrophoresis at pH 8.6, and constituted about 20 per cent of the total hemoglobin present. The following report concerns a patient with a similar I-A electrophoretic hemoglobin pattern in whom the I hemoglobin constitutes 70 per cent of the total hemoglobin. Despite the absence of S hemoglobin in the red cells of this patient, the sodium metabisulfite sickling test was found to be positive.2 Clinical DataJ.W., a twenty-five-year-old Negro woman, . . .Keywords
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