Studies on the Metabolism of 5-Hydroxytryptamine (Serotonin) II. Effect of Tryptophan Deficiency in Rats

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Abstract
Tryptophan-deficient rats showed significant decrease of 5-hydroxytryptamine (5-HT) in all tissues analyzed. Feeding of sulfasuxidine, presumably through its antibacterial action, led to greater recovery of intestinal serotonin in tryptophan-deficient rats. Injection of phenylisopropyl hydrazine resulted in a statistically significant increase of 5-HT in the blood but not in the brain of deficient animals.