Distribution of γE-Forming Cells in Lymphoid Tissues of the Human and Monkey

Abstract

The sites of synthesis of immunoglobulin E were studied by the fluorescent antibody technique. Frozen sections of human and monkey tissues were treated with guinea pig anti-γE and stained by fluorescent antibody against guinea pig immunoglobuins. The results showed that γE-forming plasma cells were predominant in the respiratory and gastrointestinal mucosa and in the regional lymph nodes. In addition to the plasma cells, the tonsils, adenoids, and broncheal and mesenteric lymph nodes contained germinal centers stained by anti-γE. In contrast, γE plasma cells were scarce in the spleen and subcutaneous lymph nodes. A possible role of locally synthesized γE immunoglobulin in respiratory allergy was discussed.