Metabolism of 2,6-dichlorobenzamide in rats and mice
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 18 (7), 817-829
- https://doi.org/10.3109/00498258809041720
Abstract
1. Oral doses of 2,6-dichlorobenzamide (DCB) were excreted by rats as DCB, two monohydroxy-DCBs, 2-chloro-5-hydroxy-6-(methylthio)benzamide and 2-chloro-5-hydroxy-6-[S-(N-acetyl)cysteinyl]benzamide (mercapturic acid). 2. Biliary excretion (33% of the dose), enterohepatic circulation and intestinal microfloral metabolism were involved in formation of 2-chloro-5-hydroxy-6-(methylthio)benzamide, and the mercapturic acid served as a precursor. 3. Whole body autoradiography and microautoradiography showed the accumulation of non-extractable. residues from DCB in the nasal mucosa and contents of the large intestines of rats and mice dosed with 14C-labelled DCB.This publication has 8 references indexed in Scilit:
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