SINEFUNGIN, A POTENT INHIBITOR OF VIRION MESSENGER-RNA(GUANINE-7-)-METHYLTRANSFERASE, MESSENGER-RNA(NUCLEOSIDE-2'-)-METHYLTRANSFERASE, AND VIRAL MULTIPLICATION
- 1 January 1978
- journal article
- research article
- Vol. 253 (12), 4075-4077
Abstract
Sinefungin (A9145) and a related metabolite, A9145C, were potent inhibitors of Newcastle disease virion and vaccinia virion mRNA(guanine-7-)methyl-transferase and vaccinia virion mRNA(nucleoside-2''-)-methyltransferase. Both Sinefungin and A9145C were competitive inhibitors of these S-adenosyl-L-methionine-dependent enzymes having inhibition constants substantially less than S-adenosyl-L-homocysteine. These compounds also inhibited plaque formation by vaccinia virus in mouse [fibroblast] L-cells.This publication has 7 references indexed in Scilit:
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