Radioimmunoassay for Human Alpha 1 -Fetoprotein
- 1 February 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (2), 526-530
- https://doi.org/10.1073/pnas.70.2.526
Abstract
A method of radioimmunoassay has been developed for the quantitation of alpha(1)-fetoprotein in human serum. The assay requires 20 mul of serum, can be completed in 8 hr, and can reproducibly detect concentrations of 20 ng of alpha(1)-fetoprotein per ml of serum. Hence, the method is about 500-fold more sensitive for the detection of alpha(1)-fetoprotein than the Ouchterlony teohnique currently in general use. The procedure is of potential clinical value as an aid in the diagnosis of cancer and a number of noncancerous hepatic diseases.Keywords
This publication has 9 references indexed in Scilit:
- Effect of therapy on the serum level of alpha-1 fetoprotein in embryonal cell carcinomaThe Journal of Pediatrics, 1972
- α-Foetoprotein in Normal Human SerumNature, 1972
- Alpha-Fetoprotein in Ontogenesis and its Association with Malignant TumorsAdvances in Cancer Research, 1971
- Isolation and characterization of a human fetal-alpha-globulin from the sera of fetuses and a hepatoma patient.1970
- THE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEMProceedings of the National Academy of Sciences, 1969
- Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.1968
- [Content of the embryo-specific alpha-globulin in the serum of the fetus, newborn infant and adult man with primary liver cancer].1965
- THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYBiochemical Journal, 1963
- PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMASTransplantation, 1963