HBsAg and HBcAg in the livers of asymptomatic hepatitis B antigen carriers.
Open Access
- 1 July 1977
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 30 (7), 671-677
- https://doi.org/10.1136/jcp.30.7.671
Abstract
Asymptomatic blood donors with persistent HBs antigenaemia have a variety of histological lesions in the liver, and serial biopsies indicate that, in some, these lesions may progress. The immunoperoxidase technique was found to be a sensitive method for the histological demonstration of HBsAg and HBcAg. Livers showing minor histological changes contained more HBsAg than those with active lesions and there appears to be an inverse relationship between the amount of HBsAg in the liver and the severity of the histological damage. In the carriers who had more than one biopsy, the presence of stainable HBsAg, irrespective of the initial histological diagnosis, was associated with a greater likelihood of progression of the histological lesion. HBcAg was found only in the hepatocyte nuclei of carriers with chronic aggressive and chronic persistent hepatitis.This publication has 20 references indexed in Scilit:
- Serial liver biopsies in blood donors with persistent HBs antigenaemia.Journal of Clinical Pathology, 1976
- DETECTION OF e ANTIGEN BY IMMUNOFLUORESCENCE IN CYTOPLASM OF HEPATOCYTES OF HBsAg CARRIERSThe Lancet, 1976
- Distribution patterns of hepatitis B surface antigen (HBsAg) in the liver of hepatitis patients.Journal of Clinical Pathology, 1976
- Detection of HBSAG in fixed liver tissue - use of a modified immunofluorescent technique and comparison with histochemical methods.Gut, 1976
- The Detection of Intracellular Antigens in Human Leucocytes by Immunoperoxidase StainingBritish Journal of Haematology, 1975
- Orcein staining of hepatitis B antigen in paraffin sections of liver biopsies.Journal of Clinical Pathology, 1975
- INTRANUCLEAR PARTICLES IN HEPATOCYTES OF HBAg-POSITIVE BLOOD-DONORSThe Lancet, 1974
- Asymptomatic liver disease in hepatitis B antigen carriersJournal of Clinical Pathology, 1974
- CELLULAR LOCALISATION OF AUSTRALIA ANTIGEN IN THE LIVER OF PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERSThe Lancet, 1970
- Australia Antigen detected in the Nuclei of Liver Cells of Patients with Viral Hepatitis by the Fluorescent Antibody TechniqueNature, 1969