Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

Abstract

Normal haematopoietic cell regulation involves interaction between marrow stromal cells and haematopoietic progenitor cells1 which may be facilitated by specific recognition and adhesion2–4. Some leukaemogenic events might produce a selective growth advantage by altering this regulatory network, possibly by diminishing the capacities of cells to adhere to stromal elements. Using an in vitro culture system which allows investigation of adhesion to stromal layers and subsequent colony formation by blast colony-forming cells (Bl–CFC) in normal marrow2–4 and Ph+ chronic myeloid leukaemic (CML) blood5, we compared the adhesive properties of normal and malignant progenitor cells. We present evidence that altered adhesive interactions between primitive progenitor cells and marrow stromal cells occur in CML.