CONTROL OF URINE FORMATION IN THE FROG BY THE RENAL CIRCULATION

Abstract

The brain was crushed, one kidney was exposed and its ureter was cannulated. 13 methods of decreasing the rate of urine formation were studied in 87 tests; all decreased either the flow of blood in the glomerular capillaries or the aortic pressure. 3 additional agents (10 tests) that produced no oliguria produced also no significant circulatory changes. The latent periods of circulatory change were similar to those for the onset of oliguria, but during recovery the excretory rate might be restored some time after the circulation improved. No oliguric agent was found that did not act on the circulatory system; hence it is believed that urine formation was diminished in all cases by decrease of mean blood pressure within glomerular capillaries.