A note on the colorimetric determination of butyrophenones with 3,5-dinitrobenzoic acid
- 1 August 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (8), 531-532
- https://doi.org/10.1111/j.2042-7158.1969.tb08306.x
Abstract
Butyrophenones react with 3,5-dinitrobenzoic acid in an alkaline medium with the formation of a red coloured complex. This reaction can be used for the quantitative determination of these drugs in pharmaceutical preparations. The influence of the ethanol concentration, the alkalinity and the reagent concentration was investigated separately. The results show that the proposed method is suitable for the assay of solutions and tablets. It requires less time than existing methods.Keywords
This publication has 3 references indexed in Scilit:
- Specific Assay Methods for Droperidol and Fentanyl Citrate in a Pharmaceutical CombinationJournal of Pharmaceutical Sciences, 1968
- A combustion method for the quantitative estimation of chromatographic spots: I. Determination of organic compounds containing fluorineJournal of Chromatography A, 1961
- Properties and Analysis of Haloperidol and Its Dosage FormsJournal of Pharmaceutical Sciences, 1961