Influence of Stress on Distribution of Endotoxin in RES Determined by Fluorescein Antibody Technic.
- 1 July 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 95 (3), 510-513
- https://doi.org/10.3181/00379727-95-23271
Abstract
1. Deposition of endotoxin of Salmonella typhosawas followed in normal and stressed rabbits by the fluorescein tagging technic. 2. Pretreatment with cortisone and x-irradiation did not affect initial phagocytosis of toxin but inhibited degradation and elimination of toxin by the RES. 3. Pretreatment with thorotrast and preliminary injection of toxin caused depression of initial phagocytic functioning of the RES to a subsequent injection of toxin. 4. Our findings in their possible relation to the generalized Shwartzman reaction were discussed.Keywords
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