An Evaluation of Some Theories of the Mechanism of Aging
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Gerontology
- Vol. 25 (3), 136-144
- https://doi.org/10.1159/000212332
Abstract
Two theories of aging are considered in this review. Although there exists substantial experimental evidence in support of the somatic mutation and error catastrophe hypotheses, several experiments have been published which are extremely difficult to reconcile with these models, at least in their simplest forms. These include the observation that biochemical and morphological degenerative changes observed in fibroblasts aged in vitro do not resemble alterations observed in cells obtained from aged donors, and the fact that tissues transplanted serially through different hosts do not decline in vigor in the manner predicted by the somatic mutation theory. Although biochemical and mutational alterations appear to accumulate in fibroblasts aged in vitro (in support of the error catastrophe model), there are substantial problems with the interpretation of such experiments, and some observations (such as the lack of increase in translational error in hemoglobin synthesis as a function of age) seem to argue directly against the error catastrophe theory. Some alternative theoretical and experimental possibilities are discussed, including the concept of programmed aging as the cause of senescence.Keywords
This publication has 11 references indexed in Scilit:
- Gene inactivation as a mechanism for the generation of variability in somatic cells cultivated in vitroMutation Research, 1977
- Heat lability of glucose-6-phosphate dehydrogenase in some senescent human cultured cells. Evidence for its postsynthetic natureBiochemical and Biophysical Research Communications, 1977
- The Status of the Gene Map of the Human ChromosomesScience, 1977
- The relationship between in vitro cellular aging and in vivo human age.Proceedings of the National Academy of Sciences, 1976
- Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.Proceedings of the National Academy of Sciences, 1976
- An Evaluation of the ‘Error Catastrophe’ Theory of Ageing in the Light of Recent Experimental ResultsGerontology, 1976
- Aging and the alteration of enzymes: A reviewMechanisms of Ageing and Development, 1975
- Testing the Protein Error Theory of Ageing: A Reply to Baird, Samis, Massie and ZimmermanGerontology, 1975
- The limited in vitro lifetime of human diploid cell strainsExperimental Cell Research, 1965
- THE FREQUENCY OF ERRORS IN PROTEIN BIOSYNTHESISBiochemical Journal, 1963